Objective: To provide reliable evidence of evidence-based medicine for the treatment and prevention of the 2019 novel coronavirus(2019-nCoV) by analyzing all the published studies on the clinical characteristics of patients with 2019-nCoV. Methods: PubMed,Cochrane Library,Embase and other databases were searched. Some studies on the clinical characteristics of 2019-nCoV infection were collected for Meta-analysis.
Results: 9 studies were included in Meta-analysis, including a total of 50404 patients with 2019-nCoV infection.According to Meta-analysis, among the clinical characteristics of patients with 2019-nCoV infection, the incidence of fever is 90.9% , the incidence of cough is 70.8%, and the incidence of muscle soreness or fatigue is 41%.
The incidence of acute respiratory distress syndrome (ARDS) was 14.8%, the incidence of abnormal chest CT was 95.6%, the proportion of severe cases in all infected cases was 21.3%, and the mortality rate of patients with 2019-nCoV infection was 4.8%.
Conclusion: Fever and cough are the most common symptoms in patients with 2019-nCoV infection, and most of them have abnormal chest CT examination.Some people have muscle soreness or fatigue, ARDS.
Diarrhea, hemoptysis, headache, sore throat, shock and other symptoms only occur in a small number of patients.
The mortality rate of patients with 2019-nCoV infection was lower than that of Severe Acute Respiratory Syndrome (SRAS) and Middle East Respiratory Syndrome (MERS).